19-nor based steroids

Non-medical users of anabolic steroids often “stack” different anabolic steroids over the course of a “cycle” of use. They also administer various ancillary drugs and substances to enhance the desired effects of anabolic steroids or to minimize adverse side effects. The most common liquid (injectable) anabolic steroids encountered in these cases are (oil-based) esters of testosterone (., testosterone cypionate, testosterone enanthate, and testosterone propionate, and a blend of testosterone esters called Sustanon 250) or nandrolone (., nandrolone decanoate). Also popular are Equipoise (boldenone undecylenate) and trenbolone acetate and trenbolone enanthate, as well as the water-based injectable Winstrol (stanozolol). Popular oral anabolic steroids include methandrostenolone (Dianbol), oxandrolone (Anavar) and oxymetholone (Anadrol 50).

As alluded to above, one very important thing to acknowledge when using AAS (whether taking one hormone, stacking or cycling) is the risk of harmful side effects. Within a steroid cycle, the users will often stack other non-anabolic hormones into their program to maximize specific cycle objectives for example: the addition of drugs like Clenbuterol and/or Cytomel /T3 augment cutting/definition cycles; others called aromatase inhibitors (estrogen reducing drugs) like Letrozole . Letro and Anastrozole Arimidex are often included to inhibit the conversion of excess testosterone to negatively cycle impacting estrogen and; incorporating post-cycle therapy (PCT) drugs such as the synthetic estrogens Tamoxifen . Nolvadex , or Clomiphene Citrate . Clomid (which act as anti-estrogens in the male body), can be used alone, together, or in conjunction with those like Mesterolone . Proviron and Human Chorionic Gonadotropin ( HCG ) during PCT to bridge the gap between the end of a steroid cycle (synthetic testosterone usage) and the restoration of the bodys natural testosterone production. These drugs too must be researched, and controlled in similar fashion to AAS. Thus, steroid cycles can be as simple or complex as the users individualized goals, cycle histories and levels of understanding. Below are three samples of AAS stacked cycles of varying complexity along with a beginning PCT sample, and an explanation of goal intention & rationale for the selected compounds, dosages & durations. These illustrations and commentaries will provide a better understanding of what stacking and cycling are along with the many nuances they require.

Androstenedione:  The test sensitivity for anabolic steroids in the standard LGC supplement screen is 10 ng/g (10 ppb). Androstenedione is known to be naturally present in milk and milk-derived products. The concentrations of androstenedione found in milk are variable, but are typically in the low ng/ml (low ppb) region. One reference cites values of around ng/ml. For this reason, the presence of androstenedione in milk or milk-derived supplement products and/or supplement ingredients analyzed using the standard LGC supplement screen is not reported unless the concentration exceeds 50 ng/g (50 ppb). 4

Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. [45]

Steroid isolation , depending on context, is the isolation of chemical matter required for chemical structure elucidation, derivitzation or degradation chemistry, biological testing, and other research needs (generally milligrams to grams, but often more [38] or the isolation of "analytical quantities" of the substance of interest (where the focus is on identifying and quantifying the substance (for example, in biological tissue or fluid). The amount isolated depends on the analytical method, but is generally less than one microgram. [39] [ page needed ] The methods of isolation to achieve the two scales of product are distinct, but include extraction , precipitation, adsorption , chromatography , and crystallization . In both cases, the isolated substance is purified to chemical homogeneity; combined separation and analytical methods, such as LC-MS , are chosen to be "orthogonal"—achieving their separations based on distinct modes of interaction between substance and isolating matrix—to detect a single species in the pure sample. Structure determination refers to the methods to determine the chemical structure of an isolated pure steroid, using an evolving array of chemical and physical methods which have included NMR and small-molecule crystallography . [2] :10–19 Methods of analysis overlap both of the above areas, emphasizing analytical methods to determining if a steroid is present in a mixture and determining its quantity. [39]

19-nor based steroids

19-nor based steroids

Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. [45]

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