Testosterone, an essential precursor of estrogen in women, is made in the ovaries and adrenal glands. There is a steady decline in testosterone levels from the 20s through menopause. With surgical menopause, the level of testosterone drops precipitously. No clear lower limit of testosterone has been established; however 15 ng per dL ( nmol per L) commonly is used. One study 38 found that women with 0 to 10 ng per dL (0 to nmol per L) had markedly decreased sexual desire in all situations and absent or markedly decreased orgasms. Because of studies like this, supplemented with anecdotal evidence, many women have been started on testosterone therapy.
Squidbillies follows the exploits of the Cuyler family and their interactions with the local populace, which usually results in a fair amount of destruction, mutilation, and death. The Cuylers are essentially given free rein and protected from the consequences of their actions whenever possible by their friend, the Sheriff (whose name is "Sharif"), as they are said to be the last twisted remnants of a federally protected endangered species , the "Appalachian Mud Squid". They live in the southern Appalachian Mountains located in northern Georgia . At the epicenter of this rural paradise is Dougal County, home to crippling gambling addictions , a murderous corporation, sexual deviants, and the authentic southern mountain squid.  In the words of The New York Times , the show takes "backwoods stereotypes" and turns them into "a cudgel with which to pound maniacally on all manner of topical subjects."