How does a disorder that damages the intestines show up on the skin? “When a person with celiac disease consumes gluten, the mucosal immune system in the intestine responds by producing a type of antibody called immunoglobulin A (IgA),” explains John Zone, MD , CDF Medical Advisory Board Member and Chairman of the Department of Dermatology at the University of Utah School of Medicine. These IgA antibodies are directed against epidermal transglutaminase. The antibodies then travel to the skin where they bind with the epidermal transglutaminase protein. Gluten ingestion seems to trigger this reaction.