Steroid eluting pacemaker leads

To achieve right atrial sensing and pacing, the connector includes, for example, a right atrial tip terminal (AR TIP) 202 adapted for connection to the atrial tip electrode 120 . A right atrial ring terminal (AR RING) 203 may also be included adapted for connection to the atrial ring electrode 121 . To achieve left chamber sensing, pacing, and shocking, the connector includes, for example, a left ventricular tip terminal (VL TIP) 204 , left ventricular ring terminal (VL RING) 205 , a left atrial ring terminal (AL RING) 206 , and a left atrial shocking terminal (AL COIL) 208 , which are adapted for connection to the left ventricular tip electrode 122 , the left atrial ring electrode 124 , and the left atrial coil electrode 126 , respectively.

This paper reports on the drug release mechanisms of silicone structures with embedded steroids applied in pacing leads. Different derivatives of the steroid dexamethasone, which is associated with the reduction of acute stimulation thresholds, were evaluated together with different matrix based release control mechanisms with the target to potentially match optimal drug release rates during the first month after implantation. By incorporating dexamethasone-21-dihydrogen phosphate in silicone matrices in combination with release rate adaption layers, almost continuous release rates were obtained under physiological test settings.

Steroid eluting pacemaker leads

steroid eluting pacemaker leads

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