Steroid induced acne pathogenesis

The aim of this article is to bring less well recognised adverse effects of inhaled corticosteroids to the attention of prescribers. Whilst inhaled steroids have a more favourable side effect profile than systemic steroids, they are not free from adverse effects. The dose of inhaled steroids used should be carefully monitored, and kept at the lowest dose necessary to maintain adequate control of the patient’s disease process. Be particularly aware of the cumulative effect of co-prescribing various dose forms of corticosteroids (inhaled, intranasal, oral and topical preparations).

Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. [45]

Typical teenage acne, so-called acne vulgaris, is characterized by three types of lesions: the comedo or blackhead; the inflammatory papule; and the pustule or pimple. Drug induced-acne can be difficult to distinguish from other sorts of acne except for the fact that it was not present prior to taking the drug. Machinists exposed to insoluble cutting oils can develop comedones at the sites of exposure. Inflammatory lesions may be less prominent. Acne can also be a part of certain hormonal problems caused by the overproduction of androgens.

Steroid induced acne pathogenesis

steroid induced acne pathogenesis

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