Epidural steroid injections are generally very safe, but there are some rare potential complications. One of the most common risks is for the needle to go too deep and cause a hole in the dura, the tissue that surrounds the spinal cord and nerve roots. When this occurs spinal fluid can leak out through the hole and cause a headache . This headache can be treated with bedrest, or with a blood patch. A blood patch involves drawing some blood from the vein and the injecting it over the hole in the dura. The blood forms a seal over the hole and prevents any further fluid from leaking out.
Prednisolone is an adrenocortical steroid used for multiple conditions including endocrine disorders, rheumatic disorders, collagen diseases, skin diseases, allergies, eye diseases, respiratory diseases, blood disorders, cancers, edematous states, gastrointestinal diseases, and nervous system disorders, among others. The brand name of this medication is discontinued, but generic versions may be available. Common side effects of prednisolone include infections, heartburn, trouble sleeping (insomnia), hunger, nausea, headache, dizziness, menstrual period changes, increased sweating, acne, and nervousness.