Steroids for pcp pneumonia

Hallucinogens are a diverse group of drugs that alter perception (awareness of surrounding objects and conditions), thoughts, and feelings. They cause hallucinations, or sensations and images that seem real though they are not. Hallucinogens can be found in some plants and mushrooms (or their extracts) or can be human-made. People have used hallucinogens for centuries, mostly for religious rituals. Common hallucinogens include the following: ayahuasca, DMT, D-lysergic acid diethylamide (LSD) ,  peyote (mescaline), and  4-phosphoryloxy-N,N-dimethyltryptamine (psilocybin) . Read the DrugFacts

PCP has also been shown to cause schizophrenia-like changes in N -acetylaspartate and N -acetylaspartylglutamate levels in the rat brain, which are detectable both in living rats and upon necropsy examination of brain tissue. [55] It also induces symptoms in humans that mimic schizophrenia. [56] PCP not only produced symptoms similar to schizophrenia, it also yielded electroencephalogram changes in the thalamocortical pathway (increased delta decreased alpha) and in the hippocampus (increase theta bursts) that were similar to those in schizophrenia. [57] PCP induced augmentation of dopamine release may link the NMDA and DA hypothesis of schizophrenia. [58]

Phencyclidine is addictive and its use often leads to psychological dependence, craving, and compulsive phencyclidine-seeking behavior. Users of phencyclidine report memory loss, difficulties with speech and learning, depression, and weight loss. These symptoms can persist up to a year after cessation of phencyclidine use. Phencyclidine has sedative effects, and interactions with other central nervous system depressants, such as alcohol and benzodiazepines, can lead to coma or accidental overdose. Use of phencyclidine among adolescents may interfere with hormones related to normal growth and development.

Trimetrexate (Neutrexin) is a significantly more potent inhibitor of DHFR than trimethoprim (Proloprim), 18 so potent that hematopoietic cells must be protected through the coadministration of leucovorin. Although trimetrexate is significantly less toxic than trimethoprim-sulfamethoxazole, it is also less effective. 21 Because it is administered once daily, trimetrexate can be used in outpatients even though it is given intravenously. To mimic the sequential enzyme blockade provided by trimethoprim-sulfamethoxazole, dapsone (100 mg orally) can be added to the regimen.

Steroids for pcp pneumonia

steroids for pcp pneumonia

Trimetrexate (Neutrexin) is a significantly more potent inhibitor of DHFR than trimethoprim (Proloprim), 18 so potent that hematopoietic cells must be protected through the coadministration of leucovorin. Although trimetrexate is significantly less toxic than trimethoprim-sulfamethoxazole, it is also less effective. 21 Because it is administered once daily, trimetrexate can be used in outpatients even though it is given intravenously. To mimic the sequential enzyme blockade provided by trimethoprim-sulfamethoxazole, dapsone (100 mg orally) can be added to the regimen.

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